number of fibres per 1000 microm(2)) and frequency (i.e. In the DC(0-300), the mean diameter of fibres > or =7.1 microm increases significantly by 5% from medial to lateral. ![]() Distinct mediolateral heterogeneity in fibre composition was found in both DC(0-300) and DLC(0-300). Considering that the effect of SCS is primarily attributed to activation of these largest fibres, it is concluded that a surprisingly small average amount of 2.4 fibres per running 0.1 mm width and 6 fibres per segmental division of the DC is involved. Only very few fibres larger than 10.7 microm were found: a mean of 68 (0.5%) in DC(0-300) and 114 (2%) in DLC(0-300). The superficial dorsolateral column (DLC(0-300)) was included in this analysis because it was hypothesized that large dorsal spinocerebellar tract fibres could also be activated by SCS. Some data was obtained from a third subject. The whole myelinated fibre population in the superficial 300 microm of the dorsal column (DC(0-300)) at Th(10-11 )of two human subjects was morphometrically analysed. Such data are indispensable to improve the predictive capability of a computer model of SCS. ![]() No data are available on the distribution of the large fibres in this superficial human DC layer at the common SCS levels Th(10-11). The largest Abeta fibres can be activated up to a maximum depth of about 0.25 mm in the DCs. In spinal cord stimulation (SCS) large diameter cutaneous (Abeta) fibres in the dorsal columns (DCs) are activated and have an inhibiting effect on the transmission of pain signals by Adelta and C fibres from the corresponding dermatome(s).
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